.Nature Medication, Published online: 18 September 2024 doi:10.1038/ s41591-024-03300-3Genomic as well as epidemiologic studies showed that an unique reassortant viral descent of the Oropouche infection, which has been distributing in the western Amazon.com location of South america for about a decade, is related to the latest human break outs in between 2022 as well as 2024.